Bioinorganic platinum chemistry

Subsitution reactions of Pt-nucleobase complexes

 
It is widely accepted that, once formed, the Pt-nucleobase complexes are inert under mild conditions and in the absence of strongly trans-labilizing ligands. By contrast, the presence of strong nucleophiles [ e.g. sulfur-containing (bio)molecules] facilitates the dissociation of N-bound nucleobases from the Pt coordination sphere.

In this work we explore the factors controlling the dissociation of different Pt-nucleobase complexes in aqueous solution in the presence of various nucleophiles giving special emphasis on the mechanism of the substitution reactions.
 
 

 

Recent publications

Mikola, M., Klika, K. D. and Arpalahti, J.: Kinetics of substitution reactions of mixed Pt(II)-nucleoside complexes in aqueous solution in the presence of thiourea. The X-ray crystal structure determination of cis-[Pt(NH3)2(adenosine-N7)2](ClO4)2x3.5H2O. Chem.–Eur. J., 6, 3404–3413, 2000.

Mikola, M., Klika, K. D., Hakala, A. and Arpalahti, J.: Substitution reactions of platinum(II)-nucleobase complexes by associative mechanism involving pseudorotation of the five-coordinate intermediate. Inorg. Chem., 38, 571–577, 1999.

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