My poster ”HSV VECTOR EXPRESSING A VARIANT OF HAS2 GENE EXHIBITS ENHANCED ONCOLYTIC EFFECT AND TUMOR SUPPRESSOR RESPONSE” is presented at the Virology Days 2025 Conference at Jyv\u00e4skyl\u00e4 6.-7.2.2025.<\/p>\n
The naked mole rat (NMR) has a long lifespan and low cancer incidence, which are linked to high molecular weight hyaluronan (HMW-HA), produced by a uniquely mutated hyaluronan synthesis 2 (HAS2) protein. To study the anti-cancer mechanism of the mutated has2<\/em> gene, we developed an attenuated replication competent HSV vector expressing the NMR-has2<\/em> gene and showed that our HSV vector causes a markedly enhanced oncolytic effect on U373MG astrocytoma cells compared to other attenuated HSV vectors and a series of wild type HSV strains [1]. In our recent study, we showed that this HSV vector produces large amounts of HMW-HA concomitantly promoting p53<\/em> expression in U373MG cells. The vector also seems to be capable of suppressing tumor growth in ovo<\/em>, although further studies are needed to confirm this result. In conclusion, our studies highlight the potential of using HSV to utilize the anti-cancer mechanism of the NMR in human cancer.<\/p><\/blockquote>\n
https:\/\/www.jyu.fi\/en\/events\/virology-days-2025-conference<\/a><\/p>\n
References<\/h4>\n
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- Palom\u00e4ki, J., Kalke, K., Orpana, J., Lund, L., Frejborg, F., Paavilainen, H., J\u00e4rvel\u00e4inen, H., & Hukkanen, V. (2023). Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy. Microorganisms, 11(11), 2657. [doi<\/a>]<\/li>\n
- Palom\u00e4ki, J., Hukkanen, V., & J\u00e4rvel\u00e4inen, H. (2024). Kaljumyyrik\u00f6n sy\u00f6p\u00e4resistenssi ja sen sovellutusmahdollisuudet tulevaisuuden l\u00e4\u00e4kekehityksess\u00e4. Solubiologi, 2024(2), 14\u201321. [www<\/a>]<\/li>\n
- Kalke, K., Orpana, J., Lasanen, T., Esparta, O., Lund, L. M., Frejborg, F., Vuorinen, T., Paavilainen, H., & Hukkanen, V. (2022). The In Vitro Replication, Spread, and Oncolytic Potential of Finnish Circulating Strains of Herpes Simplex Virus Type 1. Viruses, 14(6). [doi<\/a>]<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
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